Harvard Brigham
Vollmer Laboratory of Nanophotonics and Biosensing



  • E. Kim, M.D. Baaske & Frank Vollmer "In Situ Observation of Single-Molecule Surface Reactions from Low to High Affinities" Advanced Materials DOI: 10.1002/adma.201603153 [online] [pdf]

  • M.D. Baaske & Frank Vollmer "Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution" Nature Photonics DOI:10.1038/nphoton.2016.177 [online] [pdf]

  • Fengchi Wu, Yuqiang Wu, Z. Niu, Frank Vollmer "Integrating a DNA Strand Displacement Reaction with a Whispering Gallery Mode Sensor for Label-Free Mercury (II) Ion Detection" Sensors 2016, 16(8), 1197; doi:10.3390/s16081197 [online] [pdf]

  • A. Mahdavi, G. Sarau, J. Xavier, T. Paraiso, S. Christiansen, F. Vollmer "Maximizing Photoluminescence Extraction in Silicon Photonic Crystal Slabs" Scientific Reports 6, 25135 DOI: 10.1038/srep25135[online] [pdf]

  • F. Vollmer et.al."Voices of Biotech" Nature Biotechnology 34, 27027, (2016)[online] [pdf]

  • Y.-J. Chen, W. Xiang, J. Klucken, F. Vollmer "Tracking micro-optical resonances for identifying and sensing novel procaspase-3 protein marker released from cell cultures in response to toxins" Nanotechnology 27, 164001 (2016)[online] [pdf]


  • M.R. Foreman, J. Swaim, F. Vollmer "Whispering Gallery Mode Sensors" Adv. Opt. Photon. 7(2), 168-240 (2015)[online] [pdf]

  • Z. Ballard, M.D. Baaske, F. Vollmer, "Stand-Off Biodetection with Free-Space Coupled Asymmetric Microsphere Cavities" Sensors 15, 8968-8980 (2015) [online] [pdf]

  • E. Kim, M.R. Foreman, M.D. Baaske, F. Vollmer, "Thermal characterisation of (bio)polymers with a temperature-stabilised whispering gallery mode microsensor" Applied Physics Letters 106, 161101 (2015), [online] [pdf]

  • S. Rosenblum, Y. Lovsky, L. Arazi, F. Vollmer, B. Dayan, "Cavity ring-up spectroscopy for ultrafast sensing with optical microresonators" Nature Communications accepted (2015), [online] [pdf] [supp.]

  • M.R. Foreman and F. Vollmer, " Optical Tracking of Anomalous Diffusion Kinetics in Polymer Microspheres" Physical Review Letters 114 (11), 118001 (2015), [online] [pdf] [supp.]

  • F. Wu, Y. Wu, Z. Niu and F. Vollmer, "Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing" Analyst, 2015, Advance Article DOI: 10.1039/C5AN00179J (Communication) [online] [pdf] [supp.]

  • BioOptics World on "Detecting Single Molecules", Jan/Feb Issue (2015). [online] [pdf]


  • F. Vollmer, "Detecting Single DNA Molecules with Optical Microcavities" SPIE Newsroom Dec (2014) DOI: 10.1117/2.1201412.005699. [online] [pdf]

  • K. A. Wilson, C. A. Finch, P. Anderson, F. Vollmer, J. J. Hickman., "Combining an optical resonance biosensor with enzyme activity kinetics to understand protein adsorption and denaturation" Biomat. 38 86-96 (2014), [online] [pdf] [supp.]

  • A. Webster, F. Vollmer and Y. Sato, "Probing biomechanical properties with a centrifugal force quartz crystal microbalance" Nature Communications 5 5284 (2014). [online] [supp.]

  • FrontispeaceFrontispeaceF. Vollmer "Taking detection to the limit: monitoring single molecule interactions on a label-free microcavity biosensor" IEEE Photonics Society Newsletter (Oct 2014) [online] [pdf]

  • M. D. Baaske, M. R. Foreman and F. Vollmer "Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform" Nature Nanotechnology (2014), doi:10.1038/nnano.2014.180 [online] [supp.] [pdf] [supp.]

  • M. R. Foreman, S. Avino, R. Zullo, H.-P. Loock, F. Vollmer and G. Gagliardi, "Enhanced nanoparticle detection with liquid droplet resonators" Eur. Phys. J. Spec. Top. 223 1971-1988 (2014). [online] [pdf]

  • F. Vollmer and H. G. L. Schwefel, "Taking detection to the limit with optical microcavities: Recent advances presented at the 560. WE Heraeus Seminar" Eur. Phys. J. Spec. Top. 223 1907-1916 (2014). [online] [pdf]

  • Y. Wu, D. Y. Zhang, P. Yin and F. Vollmer "Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity" Small 10, 2067-2076 (2014). [online] [pdf] [supp.]

  • M. R. Foreman, W.-L. Jin and F. Vollmer "Optimizing detection limits in whispering gallery mode biosensing" Opt. Express 22, 5491-5511 (2014). [online] [pdf]

  • Y. Wu and F. Vollmer "Whispering Gallery Mode Biomolecular Sensors", Chapter in Cavity-Enhanced Spectroscopy and Sensing, 323-349, Springer Series in Optical Sciences 179, (Springer 2014). [online]


  • L. Shao, X.-F. Jiang, X.-C. Yu, B.-B. Li, W. R. Clements, F. Vollmer, W. Wang, Y.-F. Xiao and Q. Gong "Detection of single nanoparticles and lentiviruses using microcavity resonance broadening" Adv. Mat. 25, 5616-5620 (2013). [online] [pdf]

  • FrontispeaceM. R. Foreman and F. Vollmer "Level repulsion in hybrid photonic-plasmonic microresonators for enhanced biodetection" Phys. Rev. A 88, 023831 (2013). [online] [pdf]

  • F. Vollmer and S. Roy, "Optical resonator based biomolecular sensors and logic devices" J. Ind. Inst. Sci. 92, 233-251 (2013). [online] [pdf]

  • M. R. Foreman and F. Vollmer "Theory of resonance shifts of whispering gallery modes by arbitrary plasmonic nanoparticles" New J. Phys 15, 083006 (2013). [online] [pdf]

  • G. Sarau, B. Lahiri, P. Banzer, P. Gupta, A. Bhattacharya, F. Vollmer, S. Christiansen "Split ring resonators: enhanced Raman scattering of graphene using arrays of split ring resonators" Adv. Opt. Mat. 1, 150 (2013). [online] [pdf]

  • A. Webster and F. Vollmer "Interference of conically scattered light in surface plasmon resonance" Opt. Lett. 38, 244-246 (2013). [online] [pdf]


  • F. Vollmer and L. Yang "Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices" Nanophotonics 1, 267-291 (2012). [online] [pdf]

  • K. Wilson and F. Vollmer "Whispering Gallery Mode Resonator Biosensors", Chapter in Encyclopedia of Nanotechnology, (Springer, 2012). [online]

  • M. A. Santiago-Cordoba, M. Cetinkaya, S. V. Boriskina, F. Vollmer and M. C. Demirel "Ultrasensitive detection of a protein by optical trapping in a photonic-plasmonic microcavity" J. Biophot. 5, 629-638 (2012). [online] [pdf]

  • FrontispeaceM. Baaske and F. Vollmer "Optical Resonator Biosensors: Molecular Diagnostic and Nanoparticle Detection on an Integrated Platform" ChemPhysChem, 13, 427-436 (2012). [online] [pdf]


  • K. A. Wilson, C. A. Finch, P. Anderson, F. Vollmer and J. J. Hickman "Whispering gallery mode biosensor quantification of fibronectin adsorption kinetics onto alkylsilane monolayers and interpretation of resultant cellular response" Biomaterials, 33, 225236 (2011). [online] [pdf]

  • M. A. Santiago-Cordoba, S. V. Boriskina, F. Vollmer and M. C. Demirel "Nanoparticle-based protein detection by optical shift of a resonant microcavity" Appl. Phys. Lett. 99, 073701 (2011). [online] [pdf]


  • S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky and F. Vollmer "Whispering gallery mode carousel--a photonic mechanism for enhanced nanoparticle detection in biosensing" Opt. Express 17, 6230-6238 (2009). [online] [pdf]


  • F. Vollmer and S. Arnold "Whispering-gallery-mode biosensing: label-free detection down to single molecules" Nat. Methods 5, 591-596 (2008). [online] [pdf]

  • F. Vollmer, S. Arnold and D. Keng "Single virus detection from the reactive shift of a whispering-gallery mode" Proc. Nat. Acad. Sci 105, 20701-20704 (2008). [online] [pdf]